Recombinant beta Catenin anticorps (AA 1-200)

N° du produit ABIN7864665

Cet anticorps Lapin Monoclonal détecte spécifiquement beta Catenin dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant beta Catenin anticorps (AA 1-200) (ABIN7864665)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Catenin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CTNNB1-6807R

Détail du produit anti-beta Catenin anticorps

Épitope: AA 1-200

Fonction: Recombinant Catenin, beta (CTNNB1) Antibody

Specificité: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogène: Recombinant fragment (around aa1-200) of human CTNNB1 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur beta Catenin

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: Catenin, beta

Sujet:

Cadherin associated protein, beta 1 88 kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1

Human breast carcinoma or prostate.

Poids moléculaire: 92kDa

ID gène: 1499, 476018

Pathways: Peptide Hormone Metabolism