IL-31 anticorps (AA 1-164)

N° du produit ABIN7864470

L’anticorps anti-IL-31 Monoclonal Souris est utilisé pour la détection de IL-31 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour IL-31 anticorps (AA 1-164) (ABIN7864470)

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-31 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: IL31-7333

Détail du produit anti-IL-31 anticorps

Épitope: AA 1-164

Fonction: Interleukin-31 / IL-33 Antibody

Specificité: IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-164) of human IL31 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur IL-31

Antigène: IL-31 (IL31) (Interleukin 31 (IL31))

Autre désignation: Interleukin-31

Sujet:

IL-31, Interleukin 31

bone marrow|colon|Detected at low levels in testis|kidney|skeletal muscle|small intestine and trachea.|thymus

Poids moléculaire: 18 kDa

ID gène: 386653, 569071

UniProt: Q6EBC2