FAP anticorps (AA 1-200)

N° du produit ABIN7862796

L’anticorps anti-FAP Monoclonal Souris est utilisé pour la détection de FAP dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour FAP anticorps (AA 1-200) (ABIN7862796)

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAP est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: FAP-4851

Détail du produit anti-FAP anticorps

Épitope: AA 1-200

Fonction: Fibroblast Activation Protein Alpha / FAP-1 Antibody

Specificité: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 1-200) of human FAP protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur FAP

Antigène: FAP (Fibroblast Activation Protein, alpha (FAP))

Autre désignation: Fibroblast Activation Protein Alpha

Sujet:

170 kDa melanoma membrane-bound gelatinase, DPPIV, FAP, FAPA, Fibroblast activation protein alpha, Integral membrane serine protease, Seprase

colon or pancreas. Fibroblast specific., Human uterus

Poids moléculaire: 88kDa

ID gène: 2191, 654370

UniProt: Q12884

Pathways: Tube Formation