HNF1B anticorps (AA 1-200)

N° du produit ABIN7865451

L’anticorps anti-HNF1B Monoclonal Souris est utilisé pour la détection de HNF1B dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour HNF1B anticorps (AA 1-200) (ABIN7865451)

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HNF1B est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: HNF1B-9518

Détail du produit anti-HNF1B anticorps

Épitope: AA 1-200

Fonction: Hepatocyte nuclear factor 1 beta (HNF1b) / Transcription Factor 2 (TCF2) Antibody

Specificité: HNF-1 (a and b), HNF-3 (a, b and g), HNF-4 (a and g) and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3a, HNF-3b and HNF-3g regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3a and HNF-3b have also been shown to be involved in gastrulation events such as body axis formation. HNF-4a and HNF-4g have been shown to be important for early embryo development. HNF-4a is expressed in liver, kidney, pancreas, small intestine, testis and colon, and HNF-4g is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3b, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transcriptional activator for at least 22 other hepatocyte enriched genes, including cytochrome P450 2C13 and a-1 antitrypsin.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human HNF1B protein (exact sequence is proprietary)

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur HNF1B

Antigène: HNF1B (HNF1 Homeobox B (HNF1B))

Autre désignation: Hepatocyte nuclear factor 1 beta

Sujet:

T2D, FJHN, HNF2, LFB3, RCAD, TCF2, HPC11, LF-B3, MODY5, TCF-2, VHNF1, ADTKD3, HNF-1B, HNF1beta, HNF-1-beta

Human kidney, pancreas or liver tissue.

Poids moléculaire: 61kDa

ID gène: 6928

UniProt: P35680

Pathways: Hormone Transport, Stem Cell Maintenance, Tube Formation