KNG1 anticorps (AA 1-200)

N° du produit ABIN7865191

L’anticorps anti-KNG1 Monoclonal Souris est utilisé pour la détection de KNG1 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour KNG1 anticorps (AA 1-200) (ABIN7865191)

Antigène: KNG1 (Kininogen 1 (KNG1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KNG1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: KNG1-7422

Détail du produit anti-KNG1 anticorps

Épitope: AA 1-200

Fonction: KNG1 / Kininogen 1 (KNG1-Heavy chain) Antibody

Specificité: Kininogen is a 644 amino acid precursor protein that is expressed by the KNG1 gene and is secreted into blood plasma. Due to alternative splicing events, several Kininogen protein derivatives exist, including Kininogen LC and Kininogen HC, both of which are produced from the Kininogen precursor and exhibit different functions throughout the cell. Kininogen HC plays an important role in blood coagulation by helping to ensure that prekallikrein and Factor XI (both of which are involved in blood coagulation) are properly situated for interaction with Factor XII. Kininogen HC releases a smaller, active protein known as bradykinin, which plays a role in smooth muscle contraction, induction of hypotension, regulation of blood glucose levels, stimulation of nociceptors and overall mediation of inflammatory responses throughout the cell. In contrast to Kininogen HC, which is involved in blood clotting, Kininogen LC is primarily associated with inhibition of thrombocyte aggregation and also functions as a strong inhibitor of cysteine proteinases.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human KNG1 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur KNG1

Antigène: KNG1 (Kininogen 1 (KNG1))

Autre désignation: KNG1

Sujet:

Alpha-2-thiol proteinase inhibitor, BDK, BK, Bradykinin included, Fitzgerald factor, FLAUJEAC FACTOR, HMW kininogen, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, LMW growth-promoting factor, Williams-Fitzgerald-Flaujeac factor

Distinct positivity in plasma and in several cases extracellular matrix along with cytoplasmic expression in kidney.

Poids moléculaire: 64 kDa (heavy chain), 53 kDa (light chain)

ID gène: 3827, 77741

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process