Recombinant TYMS anticorps (AA 1-200)

N° du produit ABIN7858722

L’anticorps anti-TYMS Monoclonal Lapin est utilisé pour la détection de TYMS dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant TYMS anticorps (AA 1-200) (ABIN7858722)

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TYMS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: TYMS-9091R

Détail du produit anti-TYMS anticorps

Épitope: AA 1-200

Fonction: Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody

Specificité: It recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human thymidylate synthase protein fragment (around aa 1-200) (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months.,Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TYMS

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Autre désignation: Thymidylate Synthase

Sujet:

dTMP synthase, TMS, TS, TSase, TYMS protein, Tyms thymidylate synthetase

5-FU-resistant colon carcinoma cell lines (NCI H630R10|MCF-Ad5 and MCF-Ad10. Testicular carcinomas.|MOLT4, Ramos|NCI H630R1), 5-FU-resistant breast cancer cell lines, HeLa, Jurkat.

Poids moléculaire: 36kDa

ID gène: 7298, 369762

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases