HMMR anticorps (AA 1-250)

N° du produit ABIN7858770

L’anticorps anti-HMMR Monoclonal Souris est utilisé pour la détection de HMMR dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour HMMR anticorps (AA 1-250) (ABIN7858770)

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HMMR est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: HMMR-8021

Détail du produit anti-HMMR anticorps

Épitope: AA 1-250

Fonction: CD168 / RHAMM Antibody

Specificité: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-250) of human HMMR protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur HMMR

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Autre désignation: CD168

Sujet:

CD168, CD168 antigen, HMMR, Hyaluronan-mediated motility receptor (RHAMM), IHABP, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility

breast cancer or placenta.|Human breast

Poids moléculaire: 85-90kDa

ID gène: 3161, 728200

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process