ICOSLG anticorps (AA 1-300)

N° du produit ABIN7858828

Cet anticorps anti-ICOSLG Monoclonal Souris (Clone ICOSL-7700) (ABIN7858828) détecte spécifiquement ICOSLG dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ICOSLG anticorps (AA 1-300) (ABIN7858828)

Antigène: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ICOSLG est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: ICOSL-7700

Détail du produit anti-ICOSLG anticorps

Épitope: AA 1-300

Fonction: ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) Antibody

Specificité: This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF±), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 1-300) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur ICOSLG

Antigène: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Autre désignation: ICOS-L

Sujet:

B7 homolog 2 (B7H2), B7 like protein Gl50, B7 related protein 1 (B7RP1), CD275, CD275 antigen, GL50, ICOS LG, ICOS ligand (ICOSL), Inducible T cell co stimulator ligand, LICOS, Transmembrane protein B7 H2 ICOS ligand

HL60|HuT78 or HUVEC lysates (WB). Human tonsil tissue (IHC).|U937

Poids moléculaire: 36kDa

ID gène: 23308, 14155

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation