CD276 anticorps (AA 100-300)

N° du produit ABIN7859004

L’anticorps anti-CD276 Monoclonal Souris est utilisé pour la détection de CD276 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour CD276 anticorps (AA 100-300) (ABIN7859004)

Antigène: CD276

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD276 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: B7H3-4313

Détail du produit anti-CD276 anticorps

Épitope: AA 100-300

Fonction: CD276 / B7-H3 Antibody

Specificité: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa100-300) of human CD276 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur CD276

Antigène: CD276

Autre désignation: CD276

Sujet:

4Ig B7 H3, B7 homolog 3, B7-H3, B7H3, B7RP-2, CD276, CD276 antigen, CD276 Molecule, Costimulatory molecule

hepatocellular carcinoma or lung carcinoma.|Human tonsil|Placenta

Poids moléculaire: B7-H3 isoforms: 57/34/53/57 kDa, glycosylated B7-H3: 90-110 kDa

ID gène: 80381, 77873

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints