BCOR anticorps (AA 100-400)

N° du produit ABIN7859050

Cet anticorps anti-BCOR Monoclonal Souris (Clone BCOR-2372) (ABIN7859050) détecte spécifiquement BCOR dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour BCOR anticorps (AA 100-400) (ABIN7859050)

Antigène: BCOR (BCL6 Co-Repressor (BCOR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCOR est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: BCOR-2372

Détail du produit anti-BCOR anticorps

Épitope: AA 100-400

Fonction: BCOR Antibody

Specificité: Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFé 79oΩB expression, thereby inhibiting NFé 79oΩB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 100-400) of human BCOR protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur BCOR

Antigène: BCOR (BCL6 Co-Repressor (BCOR))

Autre désignation: BCOR

Sujet:

ANOP2, BCL 6 interacting corepressor, BCL6 interacting corepressor, BCoR, KIAA1575, MAA2, MCOPS2

Ubiquitously expression.

Poids moléculaire: 192kDa

ID gène: 54880, 659681

UniProt: Q6W2J9