APOH anticorps (AA 145-345)

N° du produit ABIN7865078

L’anticorps anti-APOH Monoclonal Souris est utilisé pour la détection de APOH dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour APOH anticorps (AA 145-345) (ABIN7865078)

Antigène: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOH est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: APOH-3705

Détail du produit anti-APOH anticorps

Épitope: AA 145-345

Fonction: Apolipoprotein H / APOH Antibody

Specificité: Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa145-345) of human APOH protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur APOH

Antigène: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Autre désignation: Apolipoprotein H

Sujet:

Activated protein C-binding protein, Anticardiolipin cofactor, APC inhibitor, Apo-H, apolipoprotein H (beta-2-glycoprotein I), B2G1, B2GP1, B2GPI, Beta 2 glycoprotein I precursor, Beta(2)GPI, BG, Glycoprotein 1, beta-2,

Human liver.

Poids moléculaire: 38kDa

ID gène: 350, 445358

UniProt: P02749