GBX2 anticorps (AA 150-350)

N° du produit ABIN7864724

Cet anticorps anti-GBX2 Monoclonal Souris (Clone GBX2-7235) (ABIN7864724) détecte spécifiquement GBX2 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GBX2 anticorps (AA 150-350) (ABIN7864724)

Antigène: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GBX2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: GBX2-7235

Détail du produit anti-GBX2 anticorps

Épitope: AA 150-350

Fonction: GBX2 / Gastrulation Brain Homeobox 2 Antibody

Specificité: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes GBX2 and OTX2. GBX2 and OTX2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, GBX2 negatively regulates OTX2 expression along the anterior-posterior axis, GBX2- mutants demonstrate an expanded OTX2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. GBX2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is overexpressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of GBX2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that GBX2 expression may be required for growth of malignant prostate cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa150-350) of human GBX2 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur GBX2

Antigène: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Autre désignation: GBX2

Sujet:

Gastrulation and brain-specific homeobox protein 2, Gastrulation brain homeobox 2, Homeobox protein GBX2, Homeobox protein STRA7, Mmoxa

Human placenta or brain.

Poids moléculaire: 37kDa

ID gène: 2637, 184945

Pathways: Dopaminergic Neurogenesis