DBH anticorps (AA 200-400)

N° du produit ABIN7864919

Cet anticorps anti-DBH Monoclonal Souris (Clone DBH-7222) (ABIN7864919) détecte spécifiquement DBH dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour DBH anticorps (AA 200-400) (ABIN7864919)

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBH est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: DBH-7222

Détail du produit anti-DBH anticorps

Épitope: AA 200-400

Fonction: DBH / Dopamine Beta-Hydroxylase Antibody

Specificité: Dopamine ≤-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa200-400) of human DBH protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur DBH

Antigène: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Autre désignation: DBH

Sujet:

dbh, DBM, Dopamine beta hydroxylase, Dopamine beta monooxygenase, Dopamine beta-hydroxylase (dopamine beta-monooxygenase), Soluble dopamine beta-hydroxylase

Human adrenal gland or adrenal pheochromocytoma.

Poids moléculaire: 78/84 kDa

ID gène: 1621, 591890

UniProt: P09172

Pathways: Carbohydrate Homeostasis