Fodrin (AA 2351-2475) anticorps

N° du produit ABIN7863430

Cet anticorps anti-Fodrin Monoclonal Souris (Clone SPTAN1-3506) (ABIN7863430) détecte spécifiquement Fodrin dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Fodrin (AA 2351-2475) anticorps (ABIN7863430)

Antigène: Fodrin

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC)

Clone: SPTAN1-3506

Détail du produit

Épitope: AA 2351-2475

Fonction: Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody

Specificité: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous °™ and æ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin °™ I and spectrin æ I are present in erythrocytes, whereas spectrin °™ II (also designated fodrin °™) and spectrin æ II (also designated fodrin æ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin °™ II, a neuronal cytoskeleton protein.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary))

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: Fodrin

Sujet:

Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2

Human colon or kidney tissues (IHC).

Poids moléculaire: 240kDa

ID gène: 6709, 372331

UniProt: Q13813