CHGB anticorps (AA 250-450)

N° du produit ABIN7859640

L’anticorps anti-CHGB Monoclonal Souris est utilisé pour la détection de CHGB dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour CHGB anticorps (AA 250-450) (ABIN7859640)

Antigène: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CHGB est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CHGB-7756

Détail du produit anti-CHGB anticorps

Épitope: AA 250-450

Fonction: Chromogranin B / CHGB (Neuroendocrine Marker) Antibody

Specificité: Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa250-450) of human CHGB protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur CHGB

Antigène: CHGB (Chromogranin B (Secretogranin 1) (CHGB))

Autre désignation: Chromogranin B

Sujet:

CCB peptide, Cg B, CgB, Chgb, SCG1, SCG1_HUMAN, Secretogranin 1, Secretogranin B, Secretogranin I, SgI

Human adrenal gland, kidney, pancreas, cerebellum or stomach.

Poids moléculaire: 76/110kDa

ID gène: 1114, 516874

UniProt: P05060