KRT14 anticorps (AA 272-472)

N° du produit ABIN7859696

Cet anticorps Souris Monoclonal détecte spécifiquement KRT14 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour KRT14 anticorps (AA 272-472) (ABIN7859696)

Antigène: KRT14 (Keratin 14 (KRT14))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KRT14 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: KRT14-6962

Détail du produit anti-KRT14 anticorps

Épitope: AA 272-472

Fonction: Cytokeratin 14 (KRT14) (Squamous Cell Marker) Antibody

Specificité: Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia. Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas. Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 272-472) of human KRT14 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur KRT14

Antigène: KRT14 (Keratin 14 (KRT14))

Autre désignation: Cytokeratin 14

Sujet:

Dowling Meara, ebs3, ebs4, Epidermolysis Bullosa Simplex, k14, Keratin Type I Cytoskeletal 14, Koebner, NFJ

Human prostate|skin or squamous cell carcinoma.

Poids moléculaire: 50kDa

ID gène: 3861, 6545380