SOX11 anticorps (AA 50-200)

N° du produit ABIN7863415

Cet anticorps anti-SOX11 Monoclonal Souris (Clone SOX11-7236) (ABIN7863415) détecte spécifiquement SOX11 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SOX11 anticorps (AA 50-200) (ABIN7863415)

Antigène: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX11 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: SOX11-7236

Détail du produit anti-SOX11 anticorps

Épitope: AA 50-200

Fonction: SOX11 (Mantle Cell Lymphoma Marker) Antibody

Specificité: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa50-200) of human SOX11 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur SOX11

Antigène: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Autre désignation: SOX11

Sujet:

SOX11, SRY (sex determining region Y) box 11, SRY related HMG box gene 11, Transcription factor SOX-11

Human tonsil or mantle cell lymphoma (MCL).

Poids moléculaire: 47kDa

ID gène: 6664, 432638

UniProt: P35716

Pathways: Tube Formation