RHOBTB2 anticorps (AA 554-604)

N° du produit ABIN7860390

L’anticorps anti-RHOBTB2 Monoclonal Souris est utilisé pour la détection de RHOBTB2 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour RHOBTB2 anticorps (AA 554-604) (ABIN7860390)

Antigène: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RHOBTB2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: DBC2-3361

Détail du produit anti-RHOBTB2 anticorps

Épitope: AA 554-604

Fonction: DBC2 / RHOBTB2 (Tumor Suppressor) Antibody

Specificité: The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Human recombinant RHOBTB2 protein fragment (around aa 554-604) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur RHOBTB2

Antigène: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Autre désignation: DBC2

Sujet:

Deleted in breast cancer 2 gene protein, p83, Rho related BTB domain containing protein 2

Human heart muscle or brain tissue.

Poids moléculaire: 83kDa

ID gène: 23221, 372688

UniProt: Q9BYZ6