Recombinant FTH1 anticorps (AA 58-180)

N° du produit ABIN7860399

L’anticorps anti-FTH1 Monoclonal Lapin est utilisé pour la détection de FTH1 dans des échantillons de Humain et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant FTH1 anticorps (AA 58-180) (ABIN7860399)

Antigène: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FTH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: FTH-8700R

Détail du produit anti-FTH1 anticorps

Épitope: AA 58-180

Fonction: Recombinant Ferritin, Heavy Chain (FTH) (Microglia Marker) Antibody

Specificité: Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human FTH1 protein fragment (around aa 58-180) (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur FTH1

Antigène: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Autre désignation: Ferritin, Heavy Chain

Sujet:

Apoferritin, Cell proliferation-inducing gene 15 protein, Ferritin H subunit, FHC, FRIH, FTH1, FTHL6, Iron overload autosomal dominant, PIG15, Placenta immunoregulatory factor, Proliferation inducing gene 15 protein (PLIF)

Human liver tissue. Liver tissue lysate, A-549, A-431, Human Brain, Rat Brain, Human Kidney, Rat Kidney, Human Lungs, Rat Lungs

Poids moléculaire: 21kDa

ID gène: 2495

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis