Recombinant CD163 anticorps (AA 956-1156)

N° du produit ABIN7864328

L’anticorps anti-CD163 Monoclonal Lapin est utilisé pour la détection de CD163 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant CD163 anticorps (AA 956-1156) (ABIN7864328)

Antigène: CD163

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD163 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: M130-8361R

Détail du produit anti-CD163 anticorps

Épitope: AA 956-1156

Fonction: Recombinant CD163 (Monocyte & Macrophage Marker) Antibody

Specificité: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 956-1156) of human CD163 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur CD163

Antigène: CD163

Autre désignation: CD163

Sujet:

Hemoglobin scavenger receptor, MM130, Scavenger receptor cysteine rich type 1 protein M130

hPBL cells. Skin|lung|placenta or histiocytoma tissue.

Poids moléculaire: 140kDa

ID gène: 9332, 504641

UniProt: Q86VB7