Recombinant MUM1 anticorps (C-Term)

N° du produit ABIN7860711

L’anticorps anti-MUM1 Monoclonal Lapin est utilisé pour la détection de MUM1 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant MUM1 anticorps (C-Term) (ABIN7860711)

Antigène: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MUM1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: MUM1-8560R

Détail du produit anti-MUM1 anticorps

Épitope: C-Term

Fonction: Recombinant MUM1 / IRF4 (Transcription Factor) Antibody

Specificité: MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (corresponding to C-terminal) of IRF4 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10  mM PBS with 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MUM1

Antigène: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Autre désignation: MUM1

Sujet:

Interferon regulatory factor 4, IRF 4, LSIRF, Lymphocyte specific interferon regulatory factor, Multiple myeloma oncogene 1, MUM1, NFEM5, PU.1 interaction partner, Sfpi1/PU.1 interaction partner, Transcriptional activator PIP

Human tonsil or diffuse large B-cell lymphoma (DLBCL).

Poids moléculaire: 52kDa

ID gène: 3662, 401013

UniProt: Q15306

Pathways: Chromatin Binding