Recombinant AMH anticorps (C-Term)

N° du produit ABIN7862897

Cet anticorps anti-AMH Monoclonal Lapin (Clone AMH-6713R) (ABIN7862897) détecte spécifiquement AMH dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant AMH anticorps (C-Term) (ABIN7862897)

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp AMH est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: AMH-6713R

Détail du produit anti-AMH anticorps

Épitope: AA 460-560, C-Term

Fonction: Recombinant Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS) Antibody

Specificité: The transforming growth factor æ (TGF æ) superfamily is composed of numerous growth and differentiation factors, including TGF æ1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin °™, æ-A, æ-B and æ-C, Lefty and Nodal. Members of the TGF æ superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Synthetic peptide from the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur AMH

Antigène: AMH (Anti-Mullerian Hormone (AMH))

Autre désignation: Anti Mullerian Hormone

Sujet:

Muellerian inhibiting factor (MIF)

Human ovary or testis.

Poids moléculaire: 70kDa (reduced), 140kDa (nonreduced)

ID gène: 268, 112432

Pathways: Negative Regulation of Hormone Secretion