Recombinant CD5 anticorps (Extracellular Domain)

N° du produit ABIN7860756

L’anticorps anti-CD5 Monoclonal Souris est utilisé pour la détection de CD5 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant CD5 anticorps (Extracellular Domain) (ABIN7860756)

Antigène: CD5

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD5 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: RC5-6976

Détail du produit anti-CD5 anticorps

Épitope: Extracellular Domain

Fonction: Recombinant CD5 (Mantle Cell Lymphoma Marker) Antibody

Specificité: The CD5 antigen is a transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10 % of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells, CD5 is weakly expressed, the intensity of expression increaing with maturation. CD5 is also expressed in a small subset of normal human B-cells (20 % of B-cells in the peripheral blood, scattered cells in the lymph node mantle zone). The CD5+ cells are probably involved in B-T interaction and their ligand is CD72 which is expressed on all B cells. It appears that CD5+ B-cells on activation primarily produce IgM. They also produce more autoantibodies than normal CD5 negative B-cells. Thus, the CD5+ B-cell population is expanded in rheumatoid arthrititis and systemic lupus erythematosus. The CD5 antibody reacts with CD5 expressed on B and T cells, and may be a useful aid for theclassification of B and T-cell malignancies. This includes B-cell chronic lymphoid leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human protein fragment corresponding to CD5 extracellular domain

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD5

Antigène: CD5

Autre désignation: CD5

Sujet:

CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

293T|or MOLT-4 cells. Human tonsil or lymph node.|Ramos

Poids moléculaire: 67kDa

ID gène: 921, 58685

UniProt: P06127