Recombinant CKM anticorps

N° du produit ABIN7861140

L’anticorps anti-CKM Monoclonal Lapin est utilisé pour la détection de CKM dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour Recombinant CKM anticorps (ABIN7861140)

Antigène: CKM (Creatine Kinase, Muscle (CKM))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CKM est non-conjugé

Application: ELISA

Clone: CKMM-13033R

Détail du produit anti-CKM anticorps

Fonction: Recombinant Creatine Kinase MM (Biomarker for Muscular Injury &, Cardiac Damage) Antibody

Specificité: Creatine kinases (CKs) are a large family of isoenzymes that regulate levels of ATP in subcellular compartments, where they provide ATP at sites of fluctuating energy demand by the transfer of phosphates between creatine and adenine nucleotides. Creatine kinases provide the energy of phosphate hydrolysis necessary to drive the normal function of many cellular systems including muscle, electrocytes, retina photoreceptor cells, brain cells, kidney, salt glands, myometrium, placenta, pancreas, thymus, thyroid, intestinal epithelial cells, endothelial cells, cartilage and bone cells, macrophages, blood platelets, and tumor and cancer cells. Human cytoplasmic creatine kinase-B, also designated CK-B and BCK, is a 381 amino acid, brain tissue-specific isoform of creatine kinase. Human cytoplasmic creatine kinase-M (CK-M, MCK) is a muscle tissue specific isoform of creatine kinase. Human cytoplasmic creatine kinase-Mi (Mi-CK, MtCK) is a 416 amino acid mitochondrial-specific isoform of creatine kinase. Cytosolic creatine kinases are important in the energetic regulation of Ca2+-pumps and in the maintenance of Ca2+-homeostasis. The antibody binds specifically to the human creatine-kinase-MM subtype (and not the MB or BB subtype). This antibody binds to human muscle creatine-kinase-MM, an enzyme that catalyzes the conversion of creatine and ATP to phosphocreatine and ADP, generating an ATP-buffer in the muscle. The antibody blocks CK-MM activity by 80 % .

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human CKM protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CKM

Antigène: CKM (Creatine Kinase, Muscle (CKM))

Autre désignation: Creatine Kinase MM

Sujet:

CKM, CKMM, Creatine kinase M, Creatine kinase M chain, Creatine kinase M type, Creatine kinase M-type, Creatine kinase muscle, Creatine kinase, muscle type, M-CK, MCK, Muscle creatine kinase

Human heart tissue. Skeletal muscle lysate.

Poids moléculaire: 43kDa

ID gène: 1158, 334347

UniProt: P06732