DNMT3A anticorps

N° du produit ABIN7862712

L’anticorps anti-DNMT3A Monoclonal Souris est utilisé pour la détection de DNMT3A dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour DNMT3A anticorps (ABIN7862712)

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DNMT3A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: PCRP-DNMT3A-1E2

Détail du produit anti-DNMT3A anticorps

Fonction: DNMT3A / DNA Methyltransferase 3 Alpha Antibody

Specificité: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Sadenosyl-L-methionin

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human full-length DNMT3A protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur DNMT3A

Antigène: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Autre désignation: DNMT3A

Sujet:

DNA methyltransferase 3 alpha, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, DNMT, DNMT3A2, M.HsaIIIA, MCMT, TBRS

HeLa cells. Placenta.

Poids moléculaire: 102kDa

ID gène: 1788, 154069

UniProt: Q9Y6K1