Fetuin anticorps

N° du produit ABIN7861308

L’anticorps anti-Fetuin Monoclonal Souris est utilisé pour la détection de Fetuin dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Fetuin anticorps (ABIN7861308)

Antigène: Fetuin

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fetuin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: AHSG-3748

Détail du produit anti-Fetuin anticorps

Fonction: Fetuin / AHSG (alpha 2-HS glycoprotein) Antibody

Specificité: Fetuin (also designated °™2-z-globulin or °™2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human AHSG protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Fetuin

Antigène: Fetuin

Sujet:

59 kDa bone sialic acid-containing protein, Aa2-066, AHS, A-2-HS-glycoprotein chain B, Alpha-2-Z-globulin, HSGA Asialofetuin, Ba-alpha-2-glycoprotein, BSP, Countertrypin, Fetua, Fetuin A, Glycoprotein PP63

Human liver, kidney, testisor placenta

Poids moléculaire: 59kDa

ID gène: 197, 324746

UniProt: P02765