GAD anticorps

N° du produit ABIN7861360

Cet anticorps anti-GAD Monoclonal Souris (Clone BICCN-GAD67-1A6) (ABIN7861360) détecte spécifiquement GAD dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GAD anticorps (ABIN7861360)

Antigène: GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GAD est non-conjugé

Application: Western Blotting (WB)

Clone: BICCN-GAD67-1A6

Détail du produit anti-GAD anticorps

Fonction: GAD1 / GAD67 (GABAergic Neuronal Marker) Antibody

Specificité: This MAb recognizes a protein of 67 kDa, which is identified as glutamic acid decarboxylase 1 (GAD1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human GAD1 (GAD67) protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur GAD

Antigène: GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Autre désignation: GAD1

Sujet:

67 kDa glutamic acid decarboxylase, CPSQ1, DCE1, GAD67, GAD1, Glutamate decarboxylase 1, SCP

K-562 or HEK293 cells. Human brain or pancreas.

Poids moléculaire: ~67kDa

ID gène: 2571, 420036

UniProt: Q99259