GCLM anticorps

N° du produit ABIN7864739

Cet anticorps Souris Monoclonal détecte spécifiquement GCLM dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GCLM anticorps (ABIN7864739)

Antigène: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GCLM est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: GCLM-4068

Détail du produit anti-GCLM anticorps

Fonction: GCLM (DNA Mismatch Repair Protein) Antibody

Specificité: G-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human GCLM protein

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur GCLM

Antigène: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Autre désignation: GCLM

Sujet:

Gamma-ECS regulatory subunit, Gamma-glutamylcysteine synthetase regulatory subunit, GCLM, GCS light chain, GLCLR, Glutamate--cysteine ligase modifier subunit, Glutamate--cysteine ligase regulatory subunit, GSC light chain

Human colon carcinoma (IHC).

Poids moléculaire: 31kDa

ID gène: 2730, 315562