Recombinant GSTM3 anticorps

N° du produit ABIN7865038

L’anticorps anti-GSTM3 Monoclonal Souris est utilisé pour la détection de GSTM3 dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant GSTM3 anticorps (ABIN7865038)

Antigène: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSTM3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RGSTM3-8878

Détail du produit anti-GSTM3 anticorps

Fonction: Recombinant Glutathione S-Transferase Mu3 (GSTM3) Antibody

Specificité: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, namely ±, é 79oΩ, é 79oΩ, é 79oΩ, 79oΩ, è 79oΩ, è 79oΩ and è 79oΩ, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM3 protein is selectively expressed in the testis and brain. GSTM3 may also be tumor suppressive in RCC, as low expression has been demonstrated to correlate with RCC risk and poor prognosis in post-op patients.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human GSTM3 protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur GSTM3

Antigène: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Autre désignation: Glutathione S-Transferase Mu3

Sujet:

brain GST antibody, brain type mu glutathione S transferase, GST class mu 3, GST5, GSTB, GSTM3-3, S (hydroxyalkyl)glutathione lyase M3, glutathione S transferase M3 (brain)

Brain|T-47D, HeLa cell lysate. Human liver|testis or kidney.

Poids moléculaire: 26kDa

ID gène: 2947, 2006

UniProt: P21266