GRAMD4 anticorps

N° du produit ABIN7861382

Cet anticorps Souris Monoclonal détecte spécifiquement GRAMD4 dans FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GRAMD4 anticorps (ABIN7861382)

Antigène: GRAMD4 (GRAM Domain Containing 4 (GRAMD4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRAMD4 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-GRAMD4-1A10

Détail du produit anti-GRAMD4 anticorps

Fonction: GRAMD4 (Transcription Factor) Antibody

Specificité: The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human GRAMD4 protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur GRAMD4

Antigène: GRAMD4 (GRAM Domain Containing 4 (GRAMD4))

Autre désignation: GRAMD4

Sujet:

Death-inducing protein, GRAM domain-containing protein 4 (GRAMD4)

heart or fetal brain., Human liver

Poids moléculaire: 66kDa

ID gène: 23151, 475150

UniProt: Q6IC98