LRP1 anticorps

N° du produit ABIN7861643

Cet anticorps Souris Monoclonal détecte spécifiquement LRP1 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour LRP1 anticorps (ABIN7861643)

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LRP1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: LRP1-7152

Détail du produit anti-LRP1 anticorps

Fonction: CD91 / LDL Receptor Related Protein 1 (LRP1) Antibody

Specificité: Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and ±-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including ±-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human LRP1 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur LRP1

Antigène: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Autre désignation: CD91

Sujet:

A2MR, Alpha 2 macroglobulin receptor, APOER, Apolipoprotein E receptor, IGFBP3R, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP-1, LRP-515, LRP-85, Lrp1, LRP1 protein, Prolow density lipoprotein receptor related protein 1, TbetaRV/LRP1/IGFBP3 receptor, TGFBR5, Type V tgf beta receptor

brain or lung.|Human liver

Poids moléculaire: 85/515/600kDa

ID gène: 4035, 162757

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling