Recombinant MVP anticorps

N° du produit ABIN7864953

Cet anticorps anti-MVP Monoclonal Souris (Clone r1032) (ABIN7864953) détecte spécifiquement MVP dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant MVP anticorps (ABIN7864953)

Antigène: MVP (Major Vault Protein (MVP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MVP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: R1032

Détail du produit anti-MVP anticorps

Fonction: Recombinant Major Vault Protein (MVP) Antibody

Specificité: Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Proteins precipitated from human breast cancer MCF-7 cells

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MVP

Antigène: MVP (Major Vault Protein (MVP))

Autre désignation: Major Vault Protein

Sujet:

Lung resistance-related protein (LRP), Major Vault Protein, MVP, VAULT1

MCF-7 or HeLa cells. Human breast tumors. Lung, Spleen, Stomach and A549

Poids moléculaire: 104-110kDa

ID gène: 9961, 632177

UniProt: Q14764