OTX2 anticorps

N° du produit ABIN7863198

Cet anticorps anti-OTX2 Monoclonal Souris (Clone PCRP-OTX2-1E10) (ABIN7863198) détecte spécifiquement OTX2 dans ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour OTX2 anticorps (ABIN7863198)

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OTX2 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: PCRP-OTX2-1E10

Détail du produit anti-OTX2 anticorps

Fonction: OTX2 / Orthodenticle homeobox 2 (Transcription Factor) Antibody

Specificité: Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human full-lengthOTX2protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur OTX2

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Autre désignation: OTX2

Sujet:

CPHD6, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC45000, Orthodenticle 2, Orthodenticle homeobox 2, Orthodenticle homolog 2 (Drosophila), Orthodenticle homolog 2, Orthodenticle2, Otx 2, otx2

Colon, HeLa cells. Human fetal gut, liver or heart.

Poids moléculaire: 71.5kDa

ID gène: 5015, 288655

UniProt: P32243

Pathways: Dopaminergic Neurogenesis