PPARD anticorps

N° du produit ABIN7861909

Cet anticorps anti-PPARD Monoclonal Souris (Clone PCRP-PPARD-4C2) (ABIN7861909) détecte spécifiquement PPARD dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PPARD anticorps (ABIN7861909)

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPARD est non-conjugé

Application: Flow Cytometry (FACS)

Clone: PCRP-PPARD-4C2

Détail du produit anti-PPARD anticorps

Fonction: PPARD Antibody

Specificité: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARa, PPARb (also designated PPARé 79oΩ) and PPARg, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARa is abundant in primary hepatocytes, where it regulates the expression of proteins involved in fatty acid metabolism. PPARb is the most widely distributed subtype and is often expressed at high levels. PPARg is predominantly seen in adipose tissue, where it plays a critical role in regulating adipocyte differentiation. Interestingly, both the orphan nuclear hormone receptor LXRa and thyroid receptor (TR) have been shown to act as antagonists of PPARa/ RXRa binding to PPREs.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around 72-146) of human PPARD protein

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur PPARD

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Autre désignation: PPARD

Sujet:

FAAR, NR1C2, NUC1, NUCII

HeLa or MCF-7 cells.

Poids moléculaire: 49.9kDa

ID gène: 5467, 696032

UniProt: Q03181

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation