Recombinant ROR gamma anticorps

N° du produit ABIN7864186

Cet anticorps Lapin Monoclonal détecte spécifiquement ROR gamma dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant ROR gamma anticorps (ABIN7864186)

Antigène: ROR gamma

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC)

Clone: RORC-8132R

Détail du produit

Fonction: Recombinant ROR-gamma / RORC (RAR-related Orphan Receptor C) Antibody

Specificité: Retina-associated orphan receptors (RORs) contains three subtypes: ROR±, ROR≤, and RORé 79oΩ. They are widely distributed in body tissues, and most of them can directly enter the nucleus to regulate the transcription of target genes, thus showing different tissue specificity and participating in different physiological processes. In particular, ROR± and RORé 79oΩ play an important role in mediating Th17 cell differentiation. RORé 79oΩ can be divided into RORé 79oΩ1 and RORé 79oΩ2 (RORé 79oΩ T), which show different tissue specificity. ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ double positive thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTi) cells of lymphoid organs. At present, RORé 79oΩ T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORé 79oΩ T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human ROR gamma T protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détail du antigène

Antigène: ROR gamma

Autre désignation: ROR-gamma

Sujet:

Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR

Human pancreas|liver or skeletal muscle tissue.

Poids moléculaire: 55kDa

ID gène: 6097

UniProt: P51449-2