Recombinant Smoothelin anticorps

N° du produit ABIN7862097

L’anticorps anti-Smoothelin Monoclonal Lapin est utilisé pour la détection de Smoothelin dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant Smoothelin anticorps (ABIN7862097)

Antigène: Smoothelin (SMTN)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Smoothelin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: SMTN-2320R

Détail du produit anti-Smoothelin anticorps

Fonction: Recombinant Smoothelin (Differentiated Smooth Muscle Marker) Antibody

Specificité: Smoothelin is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. It is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this antibody an attractive diagnostic tool. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics (-).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human Smoothelin (SMTN) protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Smoothelin

Antigène: Smoothelin (SMTN)

Autre désignation: Smoothelin

Sujet:

FLJ35168, FLJ35365, FLJ35620, FLJ38597, Smoothelin, SMSMO, Smtn, SMTN_HUMAN

Human smooth muscle.

Poids moléculaire: 59/110kDa (short/long isoforms|respectively)

ID gène: 6525, 149098

UniProt: P53814