Recombinant TPO anticorps

N° du produit ABIN7862182

Cet anticorps anti-TPO Monoclonal Souris (Clone rTPO-7248) (ABIN7862182) détecte spécifiquement TPO dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant TPO anticorps (ABIN7862182)

Antigène: TPO

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC)

Clone: RTPO-7248

Détail du produit

Fonction: Recombinant TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody

Specificité: Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. 79oΩMalignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human TPO (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détail du antigène

Antigène: TPO

Sujet:

MSA, TDH2A, Thyroid microsomal antigen, Thyroid peroxidase, Thyroperoxidase, TPO, TPX

Human thyroid carcinoma.

Poids moléculaire: 100kDa

ID gène: 7173, 467554

UniProt: P07202