Tropomyosin anticorps

N° du produit ABIN7862223

L’anticorps anti-Tropomyosin Monoclonal Souris est utilisé pour la détection de Tropomyosin dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Tropomyosin anticorps (ABIN7862223)

Antigène: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tropomyosin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TPM1-4510

Détail du produit anti-Tropomyosin anticorps

Fonction: Tropomyosin, alpha-1 chain (striated muscle) Antibody

Specificité: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin ± is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length TPM1 protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Tropomyosin

Antigène: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Autre désignation: Tropomyosin, alpha-1 chain

Sujet:

Alpha tropomyosin, TM2, CMD1Y, Tropomyosin, skeletal muscle alpha

Human heart.

Poids moléculaire: 35-45kDa

ID gène: 7168, 133892

UniProt: P04268

Pathways: Regulation of Actin Filament Polymerization