Tryptophan Hydroxylase 1 anticorps

N° du produit ABIN7864536

Cet anticorps anti-Tryptophan Hydroxylase 1 Monoclonal Souris (Clone TPH1-7661) (ABIN7864536) détecte spécifiquement Tryptophan Hydroxylase 1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Tryptophan Hydroxylase 1 anticorps (ABIN7864536)

Antigène: Tryptophan Hydroxylase 1 (TPH1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tryptophan Hydroxylase 1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TPH1-7661

Détail du produit anti-Tryptophan Hydroxylase 1 anticorps

Fonction: TPH1 / Tryptophan Hydroxylase 1 Antibody

Specificité: Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, LDOPA, which is used as a common therapy for Parkinson s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human TPH1 protein

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Tryptophan Hydroxylase 1

Antigène: Tryptophan Hydroxylase 1 (TPH1)

Autre désignation: TPH1

Sujet:

Indoleacetic acid 5 hydroxylase, L tryptophan hydroxylase, MGC119994, TPRH, TRPH, Tryptophan 5 hydroxylase 1, Tryptophan 5 monooxygenase 1, Tryptophan 5 monooxygenase

Human brain or kidney.

Poids moléculaire: 50.9kDa

ID gène: 7166, 591999

UniProt: P17752

Pathways: Feeding Behaviour