WTAP anticorps

N° du produit ABIN7865027

L’anticorps anti-WTAP Monoclonal Souris est utilisé pour la détection de WTAP dans des échantillons de Humain. Il a été validé pour IHC et FACS.

Aperçu rapide pour WTAP anticorps (ABIN7865027)

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WTAP est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: PCRP-WTAP-1A4

Détail du produit anti-WTAP anticorps

Fonction: WTAP Antibody

Specificité: Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human WTAP protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur WTAP

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Autre désignation: WTAP

Sujet:

Female-lethal(2)D homolog, hFL(2)D, PNAS132, Pre-mRNA-splicing regulator WTAP, Putative pre mRNA splicing regulator female lethal(2D), Wilms' tumour 1-associating protein, WT1 associated protein

Ubiquitous expression.

Poids moléculaire: 44.2kDa

ID gène: 9589, 446091

UniProt: Q15007