Recombinant FLI1 anticorps (AA 200-400)

N° du produit ABIN7862359

Cet anticorps anti-FLI1 Monoclonal Lapin (Clone FLI1-8318R) (ABIN7862359) détecte spécifiquement FLI1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant FLI1 anticorps (AA 200-400) (ABIN7862359)

Antigène: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FLI1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: FLI1-8318R

Détail du produit anti-FLI1 anticorps

Épitope: AA 200-400

Fonction: Recombinant FLI1 (Ewing s Sarcoma & Endothelial Marker) Antibody

Specificité: Recognizes a protein of 51 kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90 % of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11,22)(q24,q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.

Purification: 200ug/ml of Ab purified from rabbit anti-serum by Protein A.

Immunogène: Recombinant fragment (around aa200-400) of human FLI1 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur FLI1

Antigène: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Autre désignation: FLI1

Sujet:

ERGB transcription factor, Ewing Sarcoma breakpoint region 2 (EWSR2), FLI1, FLI1 EWS fusion gene, Friend leukemia integration 1 (FLI1) transcription factor, Friend leukemia virus integration 1, Proto-oncogene Fli-1, SIC1, Transcription factor ERGB, Viral integration region FLI1

Ewing s sarcoma (EWS) or angiosarcoma.|THP1 or Raji cells. Human tonsil, Ramos

Poids moléculaire: 51kDa

ID gène: 2313, 504281