LY75/DEC-205 anticorps (AA 1006-1130)

N° du produit ABIN7863090

Cet anticorps anti-LY75/DEC-205 Monoclonal Souris (Clone CD205-3720) (ABIN7863090) détecte spécifiquement LY75/DEC-205 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour LY75/DEC-205 anticorps (AA 1006-1130) (ABIN7863090)

Antigène: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LY75/DEC-205 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CD205-3720

Détail du produit anti-LY75/DEC-205 anticorps

Épitope: AA 1006-1130

Fonction: CD205 / LY75 / DEC-205 Antibody

Specificité: DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Purification: 200ug/ml of recombinant MAb purified by Protein A/G.

Immunogène: Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur LY75/DEC-205

Antigène: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Autre désignation: CD205

Sujet:

C-type lectin domain family 13 member B, CD205 antigen, CLEC13B, DEC205, gp200 MR6, LY75, Lymphocyte antigen 75, Renal Cell Carcinoma (gp200)

Human tonsil, Thymus or Lymph Node.

Poids moléculaire: 198kDa

ID gène: 4065, 100526664, 153563

UniProt: O60449