Plasma Cell Marker anticorps

N° du produit ABIN7865714

Cet anticorps Souris Monoclonal détecte spécifiquement Plasma Cell Marker dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Plasma Cell Marker anticorps (ABIN7865714)

Antigène: Plasma Cell Marker

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC)

Clone: EBS-O-231

Détail du produit

Fonction: anti-Plasma-Cell-Marker mouse monoclonal, EBS-O-231, purified

Réactivité croisée (Details): not with rat

Purification: affinity chromatography

Immunogène: pancreatic cancer related serum mucin

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optional[ICC/IF_dilution]: 1:50-1:100 (1-2 μg/mL, microwave treatment in 10 mM citrate buffer pH 6.0 recommended)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: store at 2 - 8 °C

Détail du antigène

Antigène: Plasma Cell Marker

Autre désignation: Plasma-Cell-Marker

Sujet: EBS-O-231 recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm, their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Positive control: Human toncil.