CD276 anticorps (PE)

N° du produit ABIN7867152

L’anticorps anti-CD276 Monoclonal Souris est utilisé pour la détection de CD276 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour CD276 anticorps (PE) (ABIN7867152)

Antigène: CD276

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD276 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 7-517

Détail du produit anti-CD276 anticorps (PE)

Fonction: Anti-Human CD276- PE Conjugated Monoclonal Antibody (Clone: 7-517)

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: monocyte-derived dendritic cells

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Stockage

Buffer: Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light,Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Détails sur CD276

Antigène: CD276

Autre désignation: CD276

Sujet:

Synonyms: B7H3, B7RP-2

Target Background:   Specificity: The mouse monoclonal antibody 7-517 recognizes an extracellular epitope of human CD276 (B7H3) transmembrane glycoprotein. Background: CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells, osteoblasts, sinonasal epithelium, and upon activation (by inflammatory cytokines) in monocytes, NK cells, T cells and B cells. Although it has been described also as a costimulatory ligand, its major role seems to be inhibitory. It regullates T cell proliferation and functions, and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow, which is the primary site of neuroblastoma relapse. CD276 (B7H3) is a type I transmembrane glycoprotein expressed on dendritic cells, osteoblasts, sinonasal epithelium, and upon activation (by inflammatory cytokines) in monocytes, NK cells, T cells and B cells. Although it has been described also as a costimulatory ligand, its major role seems to be inhibitory. It regullates T cell proliferation and functions, and may provide certain tumors with protection against NK cells. CD276 can be used as a marker of neuroblastoma cells in the bone marrow, which is the primary site of neuroblastoma relapse.

ID gène: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints