CCL23 anticorps (AA 1-120)

N° du produit ABIN7868017

Cet anticorps anti-CCL23 Monoclonal Souris (Clone CCL23-4034) (ABIN7868017) détecte spécifiquement CCL23 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CCL23 anticorps (AA 1-120) (ABIN7868017)

Antigène: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCL23 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CCL23-4034

Détail du produit anti-CCL23 anticorps

Épitope: AA 1-120

Fonction: CCL23 Antibody / MPIF-1

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-120) from the human protein was used as the immunogen for the CCL23 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the CCL23 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Myeloid Progenitor Inhibitory Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CCL23

Antigène: CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))

Autre désignation: CCL23

Sujet: Small inducible cytokine A23 precursor (CCL23), also called CK-b-8 and Myeloid Progenitor Inhibitory Factor 1 (MPIF-1), is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.

UniProt: P55773