ATOH7 anticorps (AA 1-134)

N° du produit ABIN7868103

L’anticorps anti-ATOH7 Polyclonal Lapin est utilisé pour la détection de ATOH7 dans des échantillons de Poisson zèbre (Danio rerio). Il a été validé pour IHC (p).

Aperçu rapide pour ATOH7 anticorps (AA 1-134) (ABIN7868103)

Antigène: ATOH7 (Atonal Homolog 7 (ATOH7))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATOH7 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ATOH7 anticorps

Épitope: AA 1-134

Fonction: Zebrafish Atoh7 Antibody / Lakritz

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Atoh7 recombinant protein (amino acids M1-L134) was used as the immunogen for the Zebrafish Atoh7 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Atoh7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Atoh7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ATOH7

Antigène: ATOH7 (Atonal Homolog 7 (ATOH7))

Autre désignation: Atoh7

Sujet: Atonal homolog 7 (Atoh7), also known as Lakritz, is a basic helix-loop-helix (bHLH) transcription factor that plays an essential role in retinal neurogenesis, particularly in the specification of retinal ganglion cells (RGCs). In zebrafish (Danio rerio), Atoh7 is critical for the early stages of eye development, where it governs the differentiation of progenitor cells into RGCs-the first retinal neurons to extend axons to the brain.

During zebrafish embryogenesis, atoh7 is expressed in retinal progenitor cells, and its activity initiates the genetic cascade required for RGC formation and optic nerve development. Mutations in atoh7, such as in the lakritz mutant, result in the complete absence of RGCs and a failure to form the optic nerve, making it a key model for studying retinal development, axonal pathfinding, and neuronal lineage commitment.

Given its conserved function across vertebrates, zebrafish Atoh7 is widely used in research on eye development, stem cell differentiation, and regenerative medicine targeting visual system repair. It also serves as a molecular marker for early neurogenesis in the retina.

UniProt: Q8AW52