OCT4 anticorps (AA 1-134)

N° du produit ABIN7868119

Cet anticorps anti-OCT4 Monoclonal Souris (Clone Oct4-3508) (ABIN7868119) détecte spécifiquement OCT4 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour OCT4 anticorps (AA 1-134) (ABIN7868119)

Antigène: OCT4 (POU5F1) (POU Class 5 Homeobox 1 (POU5F1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OCT4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Oct4-3508

Détail du produit anti-OCT4 anticorps

Épitope: AA 1-134

Fonction: Oct4 Antibody / POU5F1

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-134 was used as the immunogen for the Oct4. antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Oct4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the Oct4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur OCT4

Antigène: OCT4 (POU5F1) (POU Class 5 Homeobox 1 (POU5F1))

Autre désignation: Oct4

Sujet: Oct4 Transcription factor that binds to the octamer motif (5). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2. Transcriptional activity is positively regulated by PKM2. Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Belongs to the POU transcription factor family. Class- 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

UniProt: Q01860

Pathways: Stem Cell Maintenance