Recombinant Calcitonin anticorps (AA 1-141)

N° du produit ABIN7868140

Cet anticorps anti-Calcitonin Monoclonal Lapin (Clone CALCA-8639R) (ABIN7868140) détecte spécifiquement Calcitonin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Calcitonin anticorps (AA 1-141) (ABIN7868140)

Antigène: Calcitonin (Calca)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Calcitonin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CALCA-8639R

Détail du produit anti-Calcitonin anticorps

Épitope: AA 1-141

Fonction: Calcitonin Antibody / CALCA / CGRP

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of human Calcitonin protein (around aa 1-141) was used as the immunogen for the Calcitonin antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the Calcitonin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Calcitonin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Calcitonin

Antigène: Calcitonin (Calca)

Autre désignation: Calcitonin

Sujet: Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or Alpha-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or Beta-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.

UniProt: P01258