C6orf130 anticorps (AA 1-152)

N° du produit ABIN7868195

Cet anticorps Lapin Polyclonal détecte spécifiquement C6orf130 dans WB, ELISA, IHC, ICC, FACS et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour C6orf130 anticorps (AA 1-152) (ABIN7868195)

Antigène: C6orf130 (OARD1) (O-Acyl-ADP-Ribose Deacylase 1 (OARD1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C6orf130 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-C6orf130 anticorps

Épitope: AA 1-152

Fonction: OARD1 Antibody / O-acetyl-ADP-ribose deacetylase 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human C6orf130/OARD1 recombinant protein (Position: M1-L152) was used as the immunogen for the OARD1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the OARD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the OARD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur C6orf130

Antigène: C6orf130 (OARD1) (O-Acyl-ADP-Ribose Deacylase 1 (OARD1))

Autre désignation: OARD1

Sujet: OARD1 antibody detects ADP-ribose glycohydrolase OARD1, encoded by the OARD1 gene on chromosome 6q14.2. OARD1 antibody is used in research on ADP-ribosylation, DNA repair, and chromatin biology. OARD1 is an enzyme that removes ADP-ribose from proteins, acting as a mono-ADP-ribosylhydrolase. This activity counteracts PARP-mediated ADP-ribosylation, a key post-translational modification involved in DNA repair, transcription, and stress signaling.

Structurally, OARD1 is a ~17 kDa protein containing a macrodomain, which mediates binding and hydrolysis of ADP-ribose groups. The macrodomain recognizes ADP-ribosylated substrates and catalyzes removal of the modification. OARD1 localizes to the nucleus, where it associates with chromatin and DNA repair complexes. Isoforms generated by alternative splicing provide additional regulatory functions.

Functionally, OARD1 regulates chromatin dynamics and DNA repair by reversing mono-ADP-ribosylation on histones and DNA repair proteins. This counter-regulation maintains genomic stability and prevents accumulation of aberrant ADP-ribose modifications. Knockdown of OARD1 leads to DNA damage sensitivity, chromatin defects, and altered transcription. Researchers use OARD1 antibody to study ADP-ribosylation signaling, chromatin regulation, and DNA repair pathways.

Clinically, OARD1 has been implicated in cancer and neurodegeneration. Altered ADP-ribosylation dynamics contribute to oncogenesis by disrupting DNA repair and transcriptional regulation. OARD1 may also influence response to PARP inhibitors, which are used to treat BRCA-deficient tumors. Mutations or dysregulation of OARD1 have been linked to neurological disorders involving DNA damage accumulation. NSJ Bioreagents provides OARD1 antibody to support cancer, neurology, and epigenetics research.

Experimentally, OARD1 antibody is used in western blotting to detect the ~17 kDa protein, in immunohistochemistry to study nuclear expression, and in chromatin immunoprecipitation to examine ADP-ribosylation regulation. Co-immunoprecipitation with OARD1 antibody identifies partners including PARP family members and DNA repair proteins.

UniProt: Q9Y530