GLIPR2 anticorps (AA 1-154)

N° du produit ABIN7868212

Cet anticorps anti-GLIPR2 Polyclonal Lapin (ABIN7868212) détecte spécifiquement GLIPR2 dans ELISA, WB, IHC, FACS et IP. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GLIPR2 anticorps (AA 1-154) (ABIN7868212)

Antigène: GLIPR2 (GLI Pathogenesis-Related 2 (GLIPR2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLIPR2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Détail du produit anti-GLIPR2 anticorps

Épitope: AA 1-154

Fonction: GLIPR2 Antibody / GLI pathogenesis-related protein 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human GLIPR2 recombinant protein (Position: M1-K154) was used as the immunogen for the GLIPR2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GLIPR2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GLIPR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GLIPR2

Antigène: GLIPR2 (GLI Pathogenesis-Related 2 (GLIPR2))

Autre désignation: GLIPR2

Sujet: GLIPR2 antibody detects GLI pathogenesis-related protein 2, a member of the pathogenesis-related (PR-1) protein superfamily implicated in autophagy regulation, cellular stress response, and tumor progression. The UniProt recommended name is GLI pathogenesis-related protein 2 (GLIPR2), also known as Golgi-associated plant pathogenesis-related protein 1 domain-containing protein 2 (GAPR-1). GLIPR2 is a lipid raft-associated protein predominantly localized to the Golgi apparatus and cytoplasmic membranes, where it contributes to membrane homeostasis and cell survival pathways.

Functionally, GLIPR2 antibody recognizes a 172-amino-acid protein that plays a dual role in regulating autophagy and cellular differentiation. GLIPR2 interacts with Beclin-1, a central component of the autophagy initiation complex, to modulate autophagosome formation. Overexpression of GLIPR2 inhibits autophagic flux, whereas its depletion enhances autophagy under stress conditions. This regulatory balance links GLIPR2 to processes such as tumor suppression, cell death, and immune modulation. The protein is expressed in multiple tissues, including liver, kidney, and lung, and its expression is inducible under oxidative or endoplasmic reticulum stress.

The GLIPR2 gene is located on chromosome 9p13.3 and encodes a secreted and membrane-associated protein characterized by a conserved CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1) domain. This structural motif enables interactions with lipids, membranes, and signaling proteins, mediating responses to cellular stress. GLIPR2 is known to form homodimers and is subject to regulation by cholesterol content in the Golgi membrane. This localization allows it to influence vesicle trafficking and protein processing under metabolic challenge.

GLIPR2 antibody is widely used in research investigating autophagy, lipid homeostasis, and tumor biology. In cancer studies, GLIPR2 functions as a modulator of epithelial-to-mesenchymal transition (EMT), influencing cell adhesion, migration, and invasion. Dysregulated GLIPR2 expression has been linked to aggressive tumor phenotypes, including hepatocellular carcinoma and renal cell carcinoma. In non-cancer contexts, GLIPR2 participates in innate immune regulation and Golgi stress adaptation. It also contributes to lung tissue integrity by modulating surfactant secretion and inflammatory signaling.

At the molecular level, GLIPR2 interacts with proteins involved in oxidative stress response and chaperone-assisted folding. Its CAP domain facilitates binding to phosphatidylinositol lipids, anchoring it to specific membrane compartments. The GLIPR2 antibody is an essential tool for detecting this protein in cell biology, immunofluorescence, and immunoblotting applications. Its detection assists in understanding Golgi function, autophagy balance, and membrane organization under normal and pathological conditions.

NSJ Bioreagents provides GLIPR2 antibody reagents validated for use in autophagy, oncology, and membrane biology research, supporting studies of stress signaling and intracellular trafficking mechanisms.

UniProt: Q9H4G4